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Subsequently, reduced iron Fe 2+ enters enterocytes through divalent metal transporter-1 (DMT1) in the apical membrane ( 3+ by heparin (Hp) or ceruloplasmin ( 3+ ), binds to the membrane protein transferrin receptor 1 (TFR1) on the cell membrane to form a complex, and enters the cell through endocytosis to form an endosome (53)

In addition, cleaved PARP and cleaved caspase-3 were upregulated under conditions of glucose deprivation in cells, GPx1 overexpression or NAC treatment (Fig

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[40] Sharma V, Rao LJM