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To view a copy of this licence, visit About this article Cite this article Wangsanut, T., Sukantamala, P
In vitro studies in N2a cells showed that ApoE4 fragments (aa 1272) interact with mitochondria and cause mitochondrial dysfunction and neurotoxicity (Chang et al., 2005)
Furthermore, it protects cells against oxidative stress, which plays a role in chronic inflammation and tissue damage
