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While showing promise in inflammatory and cancer disease models, these approaches face clinical translation challenges including DAMP molecular heterogeneity, inefficient drug delivery systems, and the complexity of multi-target synergistic mechanisms

In one clinical study, meso-2,3-dimercaptosuccinic acid (DMSA) effectively reduced levels of lead and mercury (Hg) and improved autistic symptoms in children with high levels of these metals [128]

In vivo iron-sulfur cluster formation

The first 30 principal components were used for unsupervised cell clustering with a resolution = 0.3, yielding a total of 22 cell clusters using the FindNeighbours and FindClusters functions