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2014 , 114 , e39-45

This deficiency is of considerable importance, as reduced folate levels could potentially hinder the responsiveness to antidepressants [22] and even lithium treatment [27]

It also helps to induct liver insulin resistance and prevent fat build-up in the liver.

Chronic stress leads to the persistent activation of the HPA axis and excessive secretion of glucocorticoids such as cortisol
