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They are simply small, pigmented spots caused by an excess of melanin

Clinical trials using combinations of CoQ10 with cross-linked hyaluronic acid (XL-HA) have shown enhanced treatment outcomes in DED patients, attributed to CoQ10s antioxidant effects and HAs inherent water retention and viscoelasticity properties, which are essential for repairing ocular tissues (Postorino et al., 2018

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Moreover, various studies have shown that changes in the level of exosome contents other than miRNAs, including protein FZD-7, can also act as diagnostic and prognostic biomarkers for NAFLD (143, 144)