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In the matrix, multiple enzymes work together to degrade misfolded, damaged, and oxidized proteins, as well as to turnover some metabolic enzymes, forming the CLPXP complex and Lon protease homolog (LONP)
J Neurovirol
doi: 10.1056/NEJMoa0802987 104 Ismail-BeigiFCravenTBanerjiMABasileJCallesJCohenRMet al
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In these systems, nicotinamide adenine dinucleotide phosphate (NADPH) acts as a source of reducing equivalents through two flavoenzymes oxidoreductases: glutathione (GSH) reductase (GR, EC 1.8.1.7) and thioredoxin (Trx) reductase (TR, EC 1.8.1.9) 23
