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By phosphorylating BAXs Ser184 site to hinder its pro-apoptotic effect and BADs (Bcl2-associated death promoter) Ser136 site to cause it to separate from Bcl2, AKT effectively inhibits apoptosis and stops the release of cytochrome c from the mitochondria [149,150]

The main pathomechanisms of melasma occurrence through the sun-exposure is depicted in Figure 1

Its potential appears to be multifaceted, acting on several biological pathways simultaneously to create a pro-healing environment

Corticosteroid and anabolic steroid use : Injections or oral ingestion of corticosteroids as well as anabolic steroids can increase ones risk for tendon rupture