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To avoid high signal variance in the baseline concentration, the starting point signal was estimated by a linear fit of the Gln4 and Glu4 signal amplitudes of the averaged concentration changes of all volunteers

Hexamethonium itself reduced tyramine-induced norepinephrine overflow in SHR, possibly explained by inhibition of presynaptic, nicotinic receptors, which stimulated vesicular release ( From these experiments, it was concluded that 1 AR functioned as a presynaptic auto-receptor in peripheral sympathetic nerves and stimulated norepinephrine release

Ungvari Z, Wolin MS, Csiszar A