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TP: Conceived, wrote, and supervised the entire manuscript

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Chemicals and antibodies The commercial sources of chemical reagents were as follows: TBH (75-91-2, Sigma-Aldrich), RSL3 (19288, Cayman), SirReal2 (S7845, Selleck), Ferrostatin 1 (ab146169, Abcam), Z-VAD-FMK (S7023, Selleck), Necrostatin-1 (S8037, Selleck), Succinyl-CoA (S1129, Sigma-Aldrich), Nicotinamide (98-92-0, Sigma-Aldrich), Vorinostat (SC0231, Beyotime), NAD+ (S2518, Sellect), C11 BODIPY 581/591 (27086, Cayman), BSO (B2515, Sigma-Aldrich), SGC-CBP30 (S7256, Sellect), Fasnall (F413416, Aladdin)