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Higher TMAO also positively associated with indicators of central adiposity, including BMI (rho = 0.107, pFDR = 0.09), visceral body fat rating (rho = 0.122, pFDR = 0.09) and waist circumference (rho = 0.119, pFDR = 0.09), after demographics adjustment (Supplementary Fig

The synthesis process includes multiple steps: Lysine residues are methylated to form -N-trimethyl-lysine (TML), which requires vitamin C, vitamin B6, niacin and iron as cofactors

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