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Keywords Inflammation, Insulin resistance, Lipid metabolism, Leptin, Metabolic dysfunction-associated fatty liver disease, MAFLD Introduction Metabolic dysfunction-associated fatty liver disease (MAFLD), the recently proposed term replacing nonalcoholic fatty liver disease according to a multi-society Delphi consensus statement, has emerged as the most common chronic liver disease, 1,2 affecting over 25% of the general adult population and more than 50% of individuals with type 2 diabetes mellitus (T2DM)

Part I: heterocyclic modifications of the core structure

Two phases of nitrergic neuropathy in streptozotocin-induced diabetic rats