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2.2 Hepatic Impairment Study 2.2.1 Study Population Male and female participants of non-childbearing potential aged between 18 and 80 years with a BMI between 18.5 and 39.9 kg/m 2 were eligible for inclusion in the hepatic impairment study

Accurately interpreting studies requires relying on the division math (Total mg Total ml = mg per ml) rather than assuming the two measurements are interchangeable

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However, it is noteworthy that ten oligonucleotide drugs have been officially approved by FDA as of January 2020 [55], which means that the technological obstacles for oligonucleotide therapeutics are being solved step by step and the development of oligonucleotide drugs targeting NNMT is still a promising method for the prevention or treatment of obesity and related T2D in the future