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[DOI] [PubMed] [Google Scholar] 160.Picconi B, Barone I, Pisani A, Nicolai R, Benatti P, Bernardi G, Calvani M, Calabresi P

The National Institute on Aging Interventions Testing Program evaluates agents hypothesized to increase healthy lifespan in genetically heterogeneous mice ( As of Cohort 11, C2017, nine agents have shown significant extension of median lifespan: acarbose, aspirin, canagliflozin, captopril, glycine, nordihydroguaiaretic acid, Protandim, rapamycin, and 17-estradiol [82,83,84,85,86,87,88,89,90]

Therefore, the transfer of acyl moieties from fatty acyl-CoA esters to carnitine also replenishes intracellular free CoA that is crucial for intermediary metabolism [53]

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