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FIGURE 1 Glutathione peroxidase 4 inactivation or depletion induces ferroptosis Glutathione peroxidase 4 (GPX4) scavenges lipid peroxides to generate lipid alcohols, which inhibits Fe 2+ induced reactive oxygen species (ROS) production (Shyu et al., 2014
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Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice
