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First, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), a class of membrane-bound enzyme complexes that catalyzes the production of superoxides, contributes to iron-dependent accumulation of lipid peroxidation during ferroptosis ( Regulators of Iron Metabolism in Ferroptosis Although the exact mechanisms related to iron in ferroptosis remain obscure, there is no doubt about the key role of iron metabolism in the process of ferroptosis, because (1) Iron chelators block ferroptotic cell death in vitro and in vivo (Figure 1), which are discussed below

Cancer Biother Radiopharm 31(2):3743 Lin SS et al (2023) Acetylshikonin induces necroptosis via the RIPK1/RIPK3-dependent pathway in lung cancer

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Their expression is tightly regulated to ensure proper recognition of bacterial PAMPs