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VLEKT is characterized by a very low total energy intake (650800 kcal per day), carbohydrate restriction to less than 30 g/day, fat intake of around 20 g/day with a preference for sources of unsaturated fats such as extra-virgin olive oil, and protein intake of 0.81.2 g/kg of reference body weight (i.e., calculated based on the patient's height) (54)

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To the best of our knowledge, this is the first report demonstrating that tripeptide DT-109 can effectively reduce atherosclerosis in nonhuman primates, establishing it as a pioneering peptide-based therapeutic agent with significant potential in treating cardiovascular and metabolic diseases

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Table 1 Relationship between gut microbiota and COPD

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