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Vitamin B12 supplied as cyanocobalamin or hydroxocobalamin acts through its coenzymes in many metabolic processes including the synthesis of myelin, essential lipoprotein for the integrity of the nervous and peripheral system (antineuritic action)

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Creams, while more cosmetically acceptable, may contain additives, such as preservatives, that can irritate sensitive skin, potentially exacerbating CHE [76, 83]