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926,927 Moreover, platelet bioenergetics can serve as a prognostic tool in acute infections such as sepsis and chronic infections such as HIV, indicating mitochondrial dysfunction and informing treatment strategies

Additionally, an in vitro experiment using H 2 O 2 -induced lens epithelial cells is conducted to validate the effects on cell proliferation, apoptosis, and the expression of key genes

3 In vitro lipedema modelling Some of the mechanisms discussed above have been studied using in vitro models that attempt to recapitulate the in vivo adipose tissue environment to elucidate cause-and-effect relationships that are not possible in patients

For mitochondrial complex I activity measurements, the mitochondrial complex I-induced OCR measurements were carried out in permeabilized cells in the presence of complex I substrates pyruvate/malate and complex II inhibitor malonate (10 mM) 18,19,48