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Oral administration of poly--glutamate, a natural product of a few Gram-positive bacteria, including Staphylococcus and Bacillus species, ameliorates AD-like dermatitis in Nc/Nga mice by suppressing the Th2-biased immune response and production of IL-17A, which may indicate it to be a desirable prebiotic for treating overactive Th17 cells involved in psoriasis (Lee et al., 2014)

In addition to less off-target effects, reversible cysteine engagement enables fine-tuning of inhibitor binding kinetics and thus residence time, which is a key feature in therapeutic applications requiring sustained target engagement 45 , similarly to applications where more rapid target disengagement is more favorable 46

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But one common and frustrating side effect continues to plague many patients: constipation