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GDF11 and geronic effects In prior publications [12,14,15,78] , we reported that supplementation of circulating GDF11 can reverse age-related deficits in multiple major organ systems, recapitulating many of the effects seen with heterochronic parabiosis

NAD + can be generated de novo in the kynurenine pathway, where Trp is oxygenated to N-formylkynurenine by tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO) 31

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