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The regenerative effects documented across studies provide a strong rationale for expanding future experimental frameworks to include systematic evaluation of pain-related outcomes, enabling the development of therapeutic strategies that integrate tissue regeneration with functional pain modulation

Catalase (CAT) isoforms are iron porphyrin enzymes that act as an efficient ROS scavenging system to protect cells from the oxidative damage caused by these two stressors (Mittler et al., 2011)

This linkage of Prx2 to the membrane appears to be through the N-terminal cytoplasmic domain of band 3, which is also the site of linkage of other cytoplasmic proteins, including metHb [98]

Other influencing factors include hormones, skin inflammation, and oxidative stress [28]