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During CRPC development, the tumor undergoes several adaptions counteracting supraphysiological androgen levels, including increased androgen synthesis, AR amplification, AR mutation, AR alternative splicing, MYC overexpression, and hyperactive STAT signaling [113,178,183,184]

and Sharif, I

Can controlling the conversion of autophagy function contribute to the treatment of cancer, neurodegenerative diseases, inflammation, cell senescence and cardiovascular diseases

History [edit] The concept of diminishing returns can be traced back to the concerns of early economists such as Johann Heinrich von Thnen, Jacques Turgot, Adam Smith, [11] James Steuart, Thomas Robert Malthus, and [12] David Ricardo