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Once reconstituted, the solution requires refrigeration at 2 to 8 degrees Celsius and should be used within 4 weeks

[99], a high concentration of vitamin B12 in the pilosebaceous follicle promotes the production of porphyrins in Propionibacterium acnes colonies (current name Cutibacterium acnes )

12 mg remains the highest-efficacy dose, but it carries a meaningfully worse GI burden and a correspondingly higher dropout risk
