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Although the changes in the x c system following NAC in AUC are not resolved, further examinations of glutamate-related neuroadaptations in animal alcohol models revealed a decrease in the drug-related enhanced hippocampal oxidized/reduced glutathione ratio levels in both male [27] and female [28] rats

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Am J Gastroenterol 2011;106:476-482

therefore, it is more plausible that an effective vascular improvement is reached in mildmoderate vasculogenic ED patients, specifically mediated by l-ARG supplementation, as demonstrated by the evidence of PSV values compatible with absence of ED in a subset of mildmoderate vasculogenic ED patients at study completion