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In silico studies further predicted NF-B as a principal target of EGCG, suggesting that its anti-inflammatory effects may be mediated through suppression of NF-B activation and downstream cytokine production (66)

IGF-I/IGF-IR signaling in osteoclasts Studies of global IGF-I KO mice showed fewer (76% of WT control) and smaller osteoclasts with fewer nuclei in the bone (65), indicating impaired osteoclastogenesis and bone resorption (Figure 2)
Aging is characterized by many brain changes that slowly alter cognitive ability

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