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According to USDA Agricultural Research Service data based on NHANES, approximately 6% of adults aged 60 and older in the United States are vitamin B12 deficient, defined as plasma B12 below 148 pmol/L (2009)

[DOI] [PMC free article] [PubMed] [Google Scholar] Martensson J, Jain A, et al

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Pretreatment with the GlyT1 inhibitors, sarcosine (competitive) and NFPS/ALX5407 (non-competitive), has been shown to promote neuroprotection in both ex vivo oxygenglucose deprivation (OGD) models and in vivo global cerebral ischemia models (Pinto et al