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Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation

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Clinical Benefits: Regulates calcium and phosphate metabolism for bone and muscle health Supports immune system modulation and reduces susceptibility to infection Associated with improved mood and reduced risk of seasonal affective symptoms May help reduce systemic inflammation Supports neuromuscular function Effective for patients with malabsorption conditions or persistent oral supplementation failure A blood test can be arranged to confirm deficiency prior to treatment, though this is not always required

Mechanistically, HHcy promoted the activation of B cells, which secreted anti-beta 2 glycoprotein I (2GPI) antibodies that target GECs to increase the number of oxidized phospholipids, thus facilitating lipid peroxidation by activating PE synthases ethanolamine kinase 2 (ETNK2) and ethanolamine-phosphatecytidylyltransferase 2 (PCYT2) [262]