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Concurrently, oxidative stress markers such as 2,3-Dihydroxybenzoic Acid (2,3-DHBA) and nitrogen oxides (NOx), along with proinflammatory cytokines like TNF- and IL-1, were elevated, accompanied by neuronal apoptosis and degeneration (Guo et al., 2024)

The ADDF explicitly states: Little human evidence exists for potential side effects. Notably, Selank was removed from Category 2 in September 2024 when nominators withdrew the substance