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Activated CAFs overproduce and cross-link extracellular matrix (ECM) components, creating a fibrotic constraint that physically blocks T-cell movement [154]
Behringer RR, Lewin TM, Quaife CJ, Palmiter RD, Brinster RL, DErcole AJ: Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice
