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For 1,4-dioxane, the most important uncertainty that may warrant discussion is the cancer MOA and quantitative impact that decision has on the risk assessment

Uncertainty Analysis Uncertainties are integral to all risk assessments, and particularly so for ecological risk assessment considering the variability of real-world ecological systems and the unknowns inherent in evaluating a substance with limited ecotoxicological information, such as 1,4-dioxane

There is no single universally agreed UK guideline specifically for B12 supplementation after gastric banding, but recommendations from BOMSS and standard UK clinical references provide useful direction