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In addition, the photoreceptor cells in diabetic mice also showed enhanced levels of iron, ROS, and MDA and reduced GSH concentration with downregulation of GPX4 and SLC7A11, and upregulation of ACSL4, FTH1 and NCOA4, which suggested that ferroptosis is also involved in the pathogenesis of photoreceptor degeneration in the development of the early stages of DR (Gao et al., 2023)

In contrast, doses used in non-medical contexts, particularly in sports doping, may be several times higher and have been reported to reach 5005000 mg per week over extended cycles (13)

Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function