foxo4 dri peptide senolytic 2024 study FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation Molecular modelling of the FOXO4-TP53
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Studies have shown that IL-4 and IL-13 activate itch-sensitive neurons in both humans and mice through IL-4R (28)

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The phosphorylation of Y1349 and Y1356 recruits SH2 effectors, such as the GRB2/SOS complex, p85 complex, and Gab1, further activating downstream pathways [17]

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