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Description
Interestingly, both in vivo and in vitro studies have shown that the accumulation of -syn in the mitochondria of human DA neurons leads to decreased complex I activity, increased production of ROS, reduced substrate-specific respiration, and increased mitophagy [86, 87]

1 2 "History & Milestones"

However, supplementation can come in handy to fill in the gaps

A aggregates and triggers a pathogenic cascade, with and secretases breaking down APP to produce A
