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The most promising compounds in the study, 1 and 2 , showed inhibitory activities with IC 50 values of 0.102 and 0.064 M, against 2.588 and 0.028 M of the positive controls, alupurinol and febuxostat (Figure 4)
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Their pioneering work used both classical radioimmunotherapy (RIT) and a pre-targeted radioimmunotherapy (PRIT), both directed against CD38, to deliver radiation specifically to MM cells
