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We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion

In cancer cells, pyruvate is continually converted to lactate in the cytoplasm, thus hampering glucose entry into mitochondria

As highlighted in a recent systematic review 37 , there remains a need for high-quality observational data on biosimilar safety