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Lin et al., Dextran-coated iron oxide nanoparticle-improved therapeutic effects of human mesenchymal stem cells in a mouse model of Parkinsons disease

3.3 Endoplasmic reticulum stress and immune activation ER stress occurs when misfolded or unfolded proteins accumulate beyond the ERs processing capacity, activating the unfolded protein response (UPR) (35)

The STAT3 factors induce the expression of SOCS proteins which consequently inhibit the function of JAK/STAT3 signaling, i.e., SOCS proteins exert a negative feedback on the JAK/STAT3 signaling induced by both insulin/IGF-1 and certain cytokine pathways

[DOI] [PubMed] [Google Scholar] 53.Shah I.U., Jadhav S.A., Belekar V.M., Patil P.S
