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We have also demonstrated that GPX4 is highly expressed in some thyroid cancer cell lines
The silencing resulted in a substantial decrease in XPF protein levels, and, interestingly, also in the protein levels of its heterodimer partner ERCC1, suggesting that XPF is needed to maintain the stability of ERCC1 and prevent its degradation (Fig
doi: 10.1007/s00702-006-0617-0 86 SchiavonM.NardiS.Dalla VecchiaF.ErtaniA
Furthermore, HER3 has six docking sites for the p85 subunit of PI3K, which facilitate the binding of HER3 and PI3K, followed by the activation of the PI3K/Akt pathway (Kawakami and Yonesaka, 2016)
