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In brief, indoleamine 2,3-dioxygenase (IDO) activity is increased during inflammation, leading to increased conversion of tryptophan to kynurenine, reducing substrate availability for serotonin synthesis

In this context, carnitine plays a pivotal role in the metabolic plasticity of cancer cells by interacting with fundamental pathways, mediators, and regulators to supply energy and biosynthetic molecules [17]

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Notably, a chronic inflammatory status can contribute to the emergence of pathological conditions such as cancer, highlighting the importance of OCTN2 and carnitine as the main substrates