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Additionally, in contrast to other drug-loaded LDH systems that typically lose surface charge during modification [26, 40], Se/LDH@PEG-M retained a positive surface charge, which may facilitate enhanced cellular internalization via electrostatic interactions with negatively charged cell membranes [41]

doi: 10.1111/j.1525-1373.1999.09995.x 27 AsayamaKDobashiKHayashibeHKatoK

Venditti, P., et al

This aggregation leads to deformation of the red blood cell into a sickle-like shape making it relatively inflexible and unable to traverse the capillary beds