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Szlzak D, Bronowicka-Adamska P, Hutsch T, Ufnal M, Wrbel M

At least 30 million high-quality reads per sample were generated and mapped to the Oryza sativa kitaake (Phytozome V3.1) or Setaria viridis (Phytozome V2.1) reference genomes [21] using Hisat2 [22]

The heme group of enzymes is very important for endothelial cells because it regulates activities of soluble guanylate cyclases (GCs), nitric oxide synthase (NOS), cytochrome P450 (CYP450), mono-oxigenase, cyclo-oxigenase (COX) and catalase (21, 22)

With regard to the substantial clinical improvement criterion, the applicant asserted that TERLIVAZ represents a substantial clinical improvement over existing technologies because among HRS patients who failed previous therapy with available off-label treatments, TERLIVAZ has been shown to significantly improve renal function