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Since chemotherapeutics had pronounced toxic effects which limit their therapeutic efficacy, while in contrast, the study by Chen et al., indicated that PTX-IONP and PTX had comparable effects on inhibiting U251 cells, but that PTX-IONP had a less potent inhibitory effect on HMC3 cells than pure PTX, indicating that IONP possesses biological safety which could restrict chemotherapy-related toxicity

This almost mirrors the evidence from Mendelian randomisation studies on genetic exposure to lifelong lower LDL-C levels, where there is a 54% relative risk reduction of coronary heart disease (95% CI, 0.41-0.52) per each 1.0mmol/L lower long-term exposure to LDL-C was