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The discrepancy in results may be attributable to the smallness of the samples in these trials
One molecule that was downregulated by nerve crush and reversed after intraperitoneal nicotine injection was PTEN
The percentage of malformed fetuses per litter also was increased in a dose-related manner at doses of up to 5 g per fetus
Here, we review the mechanisms of mtDNA release that triggers immune responses in the brain, and we highlight its potential as a therapeutic target in aging brain and NDDs
