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An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization
The robust regulation of CDO in mammalian tissues by intracellular Cys levels and the direct correspondence of Cys levels with CDO levels in liver and adipose tissue suggest that CDO plays a role in controlling steady-state intracellular Cys levels

Consequently, inhibiting/conquering ROS production and augmentation of cellular antioxidant machinery alleviated 5-FU-associated kidney damage (42, 43)
