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Johns Wort and PPR, for example, induce CYP3A4 and P-gp, increasing the clearance of oral contraceptives, antivirals, and immunosuppressants (84)

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Variant genotypes of the GSTP1 Ile105Val gene polymorphism may contribute to the risk of chronic myelogenous leukemia (137-139)

2.3 Role of mitochondria in disease progression Disease progression is a central theme in human pathology and is the overwhelming determinant in the morbidity and mortality associated with all diseases, especially those associated with chronic inflammation