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De Groote, D

Consequently, increased CXCL9 secretion is associated with favorable immunotherapy responsiveness [76]

Enzymes such as urease and catalase can lose up to 50% of their potency after shaking, fibrinogen clotting activity is decreased after shear stress, and recombinant IL-2 and recombinant interferon activity is substantially affected by aggregation from shaking and shearing (2)

Research estimates that endogenous creatine synthesis can consume roughly half of SAM-derived methyl groups under some conditions
