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doi: 10.1007/s40265-018-0998-z 112 JanjigianYYVakianiEKuGYHerreraJMTangLHBouvierNet al

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Similarly, BCAA elevation in DKD reflects both impaired renal catabolism (reduced mitochondrial BCKDH activity) and insulin resistance-driven alterations (133), with standard eGFR adjustment being insufficient as GFR lies on the causal pathway between metabolites and outcomes

The regulation of iron absorption and homeostasis