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In this trial, once-weekly cagrilintide-semaglutide for 68 weeks in adults with overweight or obesity was highly effective and led to substantial and clinically meaningful weight loss, the authors concluded
[50] found that activated ERK1/2 played a pro-apoptotic role by inducing BAX expression, MMP depolarization, mitochondrial Cyto-C release and caspase3 upregulation, which was in line with our findings
