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GSTO1 has been shown to play a significant role in the protein glutathionylation cycle exhibiting both glutathionylation and deglutathionylation activities 11,15

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(2) GSH depletion induced by APAP leads to decreased cellular NADPH/NADP + ratios, which is known to activate glucose-6-phosphate dehydrogenase allosterically to enhance oxidative pentose phosphate pathway flux

Understanding Multiple Sclerosis and Research Innovations Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, leading to symptoms such as fatigue, difficulty walking, and muscle weakness