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Likewise, ATG5 knockdown or CQ attenuated protein levels of other lymphatic markers, including LYVE1, the transcription factors (TFs) Nuclear Receptor 2F2 (NR2F2), and PROX1, which control VEGFR3 signaling and LEC identity 1,19,20,21 (Fig

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However, the hydrophobic pocket formed by the three aromatic residues has been suggested to shield the catalytic nucleophile from bulk solvent and activating hydrolysis

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