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The activity of Parkin in the clearance of ubiquitinated A in AD models involves beclin-dependent autophagy

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G., Willemen, H

H 2 O 2 , for instance, exerts its influence by inhibiting autophagy-related protein 4 (ATG4), thereby bolstering lipidated microtubule-associated protein 1 light chain 3-II (LC3-II levels), which facilitates LC3-II binding to autophagosomes and promotes p62 oligomerization, enhancing autophagosome biogenesis [116, 117]
